Charles River - Molecular Pathology

Molecular Pathology

Charles River offers molecular pathology services that include in situ hybridization (ISH), real-time PCR (rt-PCR) and quantitative PCR (Q-PCR). Our staff has a strong background in molecular biology and histopathology. This integration means we can relate gene expression to tissue histomorphology in both normal tissues and therapeutic models of disease, providing our clients with valuable functional genomics information. The end result is the best possible interpretation and troubleshooting of molecular-based tools applied to toxicological pathology issues.

Charles River performs both non isotopic and non-isotopic in situ hybridization for cell-specific localization of expressed genes in frozen and paraffin-embedded tissues. The detection of DNA and/or mRNA by in situ hybridization allows us to localize target DNA and/or gene expression to specific cell types in tissue sections. This enables our pathologists to assess the toxicity, efficacy, and biological function of novel therapeutic compounds.

We provide a wide range of services in support of in situ gene expression studies, including:

Procurement, embedding, and sectioning of study tissues
Synthesis of DNA and RNA probes (isotopic and non-isotopic)
Optimized hybridization
Histological evaluation by board-certified pathologists
Reporting includes representative color photomicrographs

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

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