Bone Research

Charles River is a world leader in contract bone research, offering a fully-integrated service in the field since 1995. We conduct bone safety and efficacy studies using rodent and non-rodent animal models to evaluate osteoporosis drugs. Bone toxicology studies, including bone end points in the toxicological evaluation of new drugs, provide reliable quantitative data on the skeleton. These techniques are now being applied to meet the requirements for skeletal evaluations in juvenile and neonatal studies. Several animal models are also available to evaluate bone healing.

Charles River routinely performs the following:

• Radiographic diagnostics (X-ray)
• Imaging using bone densitometry techniques
• Biochemical markers of bone and/or cartilage turnover
• Histomorphometry and histology
• Biomechanical strength testing
• Micro-CT scanning

Recognizing the importance of cartilage and joint integrity, Charles River offers several animal models of arthritis with expertise in intra-articular delivery of test materials.

Animal Models for Bone and Cartilage Evaluations

• Ovariectomy-induced bone loss for osteoporosis drug testing
• 5/6 nephrectomy model
• TPTx (thyroparathyroidectomy) model
• Periosteal injection model in weanling rats (screen for anabolic agents)
• Schenk model in weanling rats (screen for anti-resorptive agents)
• Bone defect models
• Orthopedic models
• Osteoarthritis models
• Rheumatoid arthritis models

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

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