Toxicology Services: General Toxicology

Charles River has performed general toxicology safety evaluation studies for the pharmaceutical, chemical, agrochemical, and consumer product industries for many years. This experience has produced a wealth of knowledge that we can now use to advise and conduct standard and novel toxicology study designs as well as to deal with unexpected findings or toxicity issues during the course of your program. Our carcinogenicity toxicology studies in rodents and toxicity studies in both rodent and non-rodent species are performed in full compliance with Good Laboratory Practice regulations. In addition, all protocols are designed to meet the regulatory requirements of the various countries in which the products are to enter clinical trials or be marketed.

Study Options

Routes of administration

• Oral (gavage, diet, capsule)
• Parenteral (intravenous, subcutaneous, intradermal, intramuscular, and intraperitoneal)
• Dermal
• Intranasal
• Intravaginal, intrapenile
• Rectal
• Ocular

Species

• Rodent
• Non-rodent (small and large animal)

Duration

• Acute to chronic toxicology studies
• 2 year carcinogenicity
• 6 month Tg.AC and P53 transgenic

In utero exposure/neurobehavioral studies

Support Services

• Analytical chemistry for dose formulation analysis
• Bioanalytical chemistry sample assays for drug concentration
• Toxicokinetics and pharmacokinetics
• Specialized statistical analyses

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

All news items

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