Charles River - Preclinical Services: Genetic Toxicology Studies

Genetic Toxicology

Genetic toxicology studies are conducted early in the safety testing program of pharmaceuticals and impurities, medical devices, chemicals, food additives, etc. Charles River conducts its genetic toxicology studies in the generally accepted tiered approach, starting with an Ames test and progressing to the conduct of mammalian cell and in vivo assays, which are designed to assess the toxicological relevance of any earlier observations.

Services

Cytotoxicity
Bacterial mutation (Ames)
Chromosome aberration using human lymphocytes or CHO cells
Mammalian cell mutation (mouse lymphoma L5178Y TK assay)
Rodent micronucleus
UDS (in vivo rodent liver and in vitro hepatocyte)

In addition, we offer special methods for the following:

Evaluating peptides
Medical devices
Screening for preliminary safety assessment
Lead compound identification
Mechanistic studies
In vitro micronucleus
Miniaturized methods for compounds with limited availability
Determination of mode of action
Target organ testing
Gases

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

All news items

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ASK CHARLES RIVER,
or call 1-877-CRIVER1.