Toxicology Services: Neurotoxicology

Adult and developmental neurotoxicology testing at Charles River Laboratories encompasses a broad range of products, including pharmaceuticals, biologics, biomaterials, chemicals, and agrochemicals. Routine screening evaluations are conducted as stand-alone studies or as components of regular subchronic and chronic safety studies. Backed by the largest historical control database for tests in developmental neurotoxicity studies, Charles River's offerings in the area of functional teratology, pediatric evaluations, and adult screening are unmatched in the industry.

In addition to standard dose routes, specialized treatment routes such as epidural, intrathecal, intracerebral, and continuous intravenous infusion, as well as inhalation and dermal exposure, can be used in rodent and nonrodent species to mimic the clinical route.

Neurobehavioral Screening

• Functional Observational Battery (FOB)
• Clinical observations
• Motor activity
• Learning and memory
• Sensory evaluation
• Motor coordination

Neuropathology

• Paraffin and/or plastic embedded
• Brain morphometry
• Histomorphometry
• Immunohistochemistry
• Cytochemical markers
• Electron microscopy
• Image analysis

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

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