Toxicology Services: Ocular Toxicology

GLP-compliant ocular toxicology studies have been conducted at Charles River Laboratories for over 10 years. This experience, plus the wide variety of equipment, procedures, and parameters available within the Charles River network, provides a service unmatched in our industry. Studies are performed via intravitreal injection, topical instillation, or various systemic routes of exposure in both small and large animal models for therapeutic agents targeting a range of diseases and conditions, such as:

• Age-related macular degeneration (AMD)
• Diabetic retinopathy
• Glaucoma
• Dry eye
• CMV retinitis
• Uveitis
• Hemorrhage clearance
• Ocular side effect (e.g., PDE5/PDE6 inhibitors)

Specialized services to support your ocular program include:

• Electroretinography
• Tonometry (IOP) evaluations
• Digital fundus photography
  • Multiple image modes (infrared, tomography for 3-D images)
  • Autoreflectance
  • Fluorescein angiography (FA)
  • Indocyanine green (ICG)
• Vitrectomy
• Quantitative Autoradiography
• Drug metabolism techniques
• Enhanced microscopic evaluation
• Light- and laser-induced efficacy models

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

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