Safety Pharmacology

The types of safety pharmacology studies that are required depend largely on the mode of action of the test material. Charles River recommends a core battery of studies for the evaluation of your test material’s effects on the central nervous system, as well as cardiovascular and respiratory function. We have established safety pharmacology models to meet current regulatory requirements for these core battery tests plus supplementary studies to support your program.

Core Battery Tests

• Central nervous system (CNS) studies in rodents and nonrodents (Functional Observational Battery or Modified Irwin Screen)
• Respiratory evaluations for routine parameters in rodents and nonrodents
• Cardiovascular studies in conscious, unrestrained naïve or non-naïve animals via telemetry or jacket and tether systems 

Supplementary Studies

• All main areas mandated by ICH S7 Guidelines
• Additional investigations for CNS, respiratory, and cardiovascular effects
• Renal
• Gastrointestinal
• Muscle and autonomic nervous system function
• Evaluation of endocrine and immune effects
• In vitro hERG and action potential duration assays 

What's New

Charles River and DSI to Co-Host Second Annual Safety Pharmacology Symposium and Workshop

Charles River Preclinical Services Announces Dates of 15th Annual Biotech Symposium

On-line Registration for the 2008 Charles River Short Course Now Available

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