Charles River offers a comprehensive analytical service to support residue and pharmacokinetic investigations. Our specialists have years of experience in the transfer of analytical methodologies to meet the regulatory requirements of any study. If a method does not exist, we offer method development with advice on the most suitable methods of extraction, separation and detection.
All data is collected and processed using validated systems. For residue studies, if the formulation is available when ADME investigations are conducted, then the marker residue analysis can be combined with the radiolabeled phase and reported together.
Methods
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HPLC (UV, fluorescence, refractive index, light scattering, electrochemical)
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GC (FID, NPD, TCD, ECD)
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LC-MS, GC-MS, GC/LC-MS-MS, time-of-flight (QToF,
IT-ToF)
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Capillary electrophoresis (UV, LIF)
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Dionex ion chromatography (conductivity detection)
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ICP-OES (Optima™ 8000)