Inhalation Toxicology

Utilizing knowledge from decades of experience in the field, Charles River offers a full range of inhalation toxicology study designs to support the worldwide registration of animal health products. In modern laboratory facilities with custom-designed apparatus, we conduct a variety of study designs in multiple species.

Study Types

  • Acute toxicity
  • Subacute to chronic
  • Reproduction and teratogenicity
  • Neurotoxicology
  • ADME/TK
  • Dry powders
  • Aerosol
  • Emulsion sprays
  • Vapors
  • Gases
  • Compound-specific methodologies can be developed and validated.
  • Sorbent tubes or impingers are used to sample test atmospheres.
  • Chemical or gravimetric assessment of test atmospheres
  • Online infrared or GC analysis for gases and vapors
  • Real-time aerosol monitors (RAM-S) for measuring particulates
  • Aerosol particle size distribution monitored using cascade impactors or laser optical systems

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Tolerance, Safety & Metabolism Studies

Our experience covers a diverse range of product types, and the related studies are fully supported in-house with clinical chemistry, veterinary pathology and statistical services.

Veterinary Field Studies

We can conduct certain dose confirmation and post-marketing studies in the field. Treatment routes have included injectables, intramammaries, water medications, oral dosing and in-feed medications.

Toxicology Studies

Leading the industry in the fields of reproductive toxicology, inhalation, infusion, bone research and other specialty toxicological assessments.