Charles River offers a comprehensive service for the isolation, analysis and identification of metabolites from biological matrices in support of compound safety and metabolism studies.
Our biotransformation chemists have many years of experience in the following areas:
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Chromatography method development
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Sample preparation method development
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Extraction of bound residues
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Radiochromatographic profiling
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Isolation and purification of metabolites
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Metabolite identification using LC-MS/MS, QToF and
IT-ToF
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Access to NMR
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Expert report preparation
Radiosynthesis
We can assist with the procurement of radiolabelled molecules on behalf of clients. This service is completely confidential, free of charge and does not commit the client to using Charles River or any of the laboratories involved. We have chemists on-site who are experienced in the handling and repurification of radiolabelled molecules, which allows us to preserve study timelines when radiolabelled molecules are unstable or impure.