Physicochemical Characterization

Our scientists have vast experience in the conduct of various physicochemical testing packages (or stand-alone tests) to assess the environmental impact and safety of an active ingredient and its formulated products.

We offer the following services to meet global regulatory requirements:

  • Physicochemical testing
  • Characterization studies
  • Technical and analytical support for toxicity, ecotoxicity and environmental fate (eFate) studies

All quantitative analytical procedures are subject to rigorous validation before use. When no analytical procedures exist, we can undertake full method development.

A validated analytical method is required to support many product chemistry and ecotoxicology tests. Experienced analysts are available to establish new analytical methods or to transfer existing methodology using a wide range of up-to-date equipment:

  • HPLC (UV/Vis, diode array, fluorescence, refractive index, light scattering, electrochemical)
  • GC (FID, ECD, FPD)
  • LC-MS, GC-MSD, LC-MS/MS, time-of-flight (QToF, IT-ToF)
  • Capillary electrophoresis (diode array, UV/Vis)
  • Dionex ion chromatography (conductivity detection)
  • ICP-OES (Optima™ 8000)
  • Solid, liquid, semi-solid and aerosol formulations
  • Real-time and accelerated storage stability testing
  • Dedicated facilities to stress the material using monitored heat, humidity or light parameters

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Analytical Support

Charles River offers a comprehensive analytical service to support residue and pharmacokinetic investigations.

Ecotoxicology Studies

Our custom-designed ecotoxicology facility is equipped to run aquatic and terrestrial ecotoxicology investigations.