Toxicology

Charles River has been conducting toxicology studies for almost 50 years and offers the complete range of studies required for veterinary pharmaceutical product registration worldwide.

  • Single-dose acute (including oral, dermal, irritation and sensitization tests)
  • Short-term and long-term (including carcinogenicity)
  • All routine routes of administration
  • Immunotoxicology
  • Neurotoxicology
  • Endocrine disruptors

We also offer the full range of reproductive and developmental toxicity studies required for product registration.

  • Reproductive toxicology screening to OECD 421 and 422
  • Developmental toxicology in rats and rabbits
  • Multigenerational studies in rats

Standard Genetic Toxicology Studies:

  • In vitro Ames test
  • Chromosomal aberration
  • Mouse lymphoma assays
  • In vitro rodent micronucleus
  • Comet assay
  • In vitro micronucleus assay

Blue Screen HC

  • Detects direct acting mutagens
  • Data available within 72 hours of dosing

Micro Ames

  • Determines genotoxic potential
  • Highly predictive of the eventual GLP study
  • Results within 96 hours of dosing

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Efficacy Studies

Charles River has extensive experience with breeding ectoparasites and the conduct of efficacy tests (in vitro and in vivo).

Analytical Support

We offer full analytical support for quantifying residues and identifying metabolites.

Veterinary Field Studies

As well as efficacy and safety, we can conduct certain dose confirmation and post-marketing studies in the field. Treatment routes have included injectables, intramammaries, water medications, oral dosing and in-feed medications.

Ecotoxicology Studies

Our custom-designed ecotoxicology facility is equipped to run aquatic and terrestrial ecotoxicology investigations.