Physicochemical Characterization, Analytical Chemistry & Stability Testing

Physicochemical testing is an integral requirement of product registration for biocides. Charles River offers all the characterization and physicochemical studies (active ingredients and formulated products) necessary to support registration worldwide, including:

  • Physical state
  • Melting point
  • Boiling point
  • Relative density
  • Surface tension
  • Water solubility
  • Organic solvent solubility
  • Octanol/water partition coefficient
  • Dissociation constant
  • Flammability
  • pH
  • Viscosity
  • Oxidizing or reducing properties
  • Rate of hydrolysis (cold)
  • Spectra (UV, UV/Vis, IR, NMR, MS)

A validated analytical method is required to support many product chemistry and ecotoxicology tests. Experienced analysts are available to establish new analytical methods or to transfer existing methodology using a wide range of up-to-date equipment:

  • HPLC (UV, LIF, fluorescence, refractive index, light scattering, electrochemical)
  • GC (FID, NPD, TCD, ECD)
  • LC-MS, GC-MS, GC/LC-MS-MS, time-of-flight
    (Q-ToF, IT-ToF)
  • Capillary electrophoresis (UV, LIF)
  • Dionex ion chromatography (conductivity detection)
  • ICP-OES (Optima™ 8000)

The storage stability and shelf-life of the formulated product can be determined under a variety of specified storage conditions. Solid, liquid, semi-solid and aerosol formulations can all be evaluated using real-time and accelerated storage stability testing. We have dedicated facilities to stress the material using monitored heat, humidity or light parameters.

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Skin Penetration Studies

Charles River performs in vitro skin penetration studies with human skin in support of biocide development.

Ecotoxicology Studies

Our custom-designed ecotoxicology facility is equipped to run aquatic and terrestrial ecotoxicology investigations.

Residue Analysis

Using samples from studies conducted at Charles River, or provided by you, we can develop assays or evaluate and modify a supplied method using a full suite of analytical techniques and instrumentation.

Toxicology Studies

Leading the industry in the fields of reproductive toxicology, inhalation, infusion, bone research and other specialty toxicological assessments.