Toxicology

Charles River has been conducting toxicology studies for almost 50 years and offers the complete range of studies required for biocidal product registration worldwide.

  • Single dose acute (including oral, dermal, irritation and sensitization tests)
  • Short-term and long-term (including carcinogenicity)
  • All routine routes of administration
  • Immunotoxicology
  • Neurotoxicology
  • Endocrine disruptors

We also offer the full range of reproductive and developmental toxicity studies required for product registration.

  • Reproductive toxicology screening to OECD 421 and 422
  • Developmental toxicology in rats and rabbits
  • Multigenerational studies in rats

Standard Genetic Toxicology Studies:

  • In vitro Ames test
  • Chromosomal aberration
  • Mouse lymphoma assays
  • In vitro rodent micronucleus
  • Comet assay
  • In vitro micronucleus assay

Blue Screen HC

  • Detects direct acting mutagens
  • Data available within 72 hours of dosing

Micro Ames

  • Determines genotoxic potential
  • Highly predictive of the eventual GLP study
  • Results within 96 hours of dosing

You may also be interested in...

Metabolism Studies

Charles River has over 30 years of experience performing rodent and livestock metabolism studies that meet international regulatory standards for biocide development.

Residue Analysis

Using samples from studies conducted at Charles River, or provided by you, we can develop assays or evaluate and modify a supplied method using a full suite of analytical techniques and instrumentation.

Skin Penetration Studies

Charles River performs
in vitro skin penetration studies with human skin in support of biocide development.