Inhalation Toxicology

Utilizing knowledge from decades of experience in the field, Charles River offers a full range of inhalation toxicology study designs to support the worldwide registration of chemicals. In modern laboratory facilities with custom-designed apparatus, we conduct a variety of study designs in multiple species.

Study Types:

  • Acute toxicity
  • Subacute to chronic
  • Reproduction and teratogenicity
  • Neurotoxicology
  • ADME/TK
  • Dry powders
  • Aerosols
  • Emulsion sprays
  • Vapors
  • Gases
  • Compound-specific methodologies can be developed and validated.
  • Sorbent tubes or impingers are used to sample test atmospheres.
  • Chemical or gravimetric assessment of test atmospheres
  • Online infrared or GC analysis for gases and vapors
  • Real-time aerosol monitors (RAM-S) for measuring particulates
  • Aerosol particle size distribution monitored using cascade impactors or laser optical systems

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REACH Services

We offer a full range of testing services which meet REACH requirements, either as packages or stand-alone studies, conducted to the appropriate guidelines.

Physicochemical Characterization

We offer a full range of physicochemical testing to meet all regulatory requirements, either as full testing programs or stand-alone tests.

Skin Penetration Studies

Charles River performs
in vitro skin penetration studies with human skin to support chemical registration.

Ecotoxicology Studies

Our custom-designed ecotoxicology facility is equipped to run aquatic and terrestrial ecotoxicology investigations.