Toxicology

Charles River has been conducting toxicology studies for almost 50 years and offers all studies required for chemical registration worldwide. We perform studies ranging from single-dose acute (including oral, dermal, irritation, and sensitization tests) to short-term and long-term (including carcinogenicity) studies in multiple species. All routine routes of administration are available, as well as specialized routes (e.g., inhalation).

We offer the full range of developmental and reproductive toxicity studies required for product registration:

  • Reproductive toxicology screening to OECD 421 and 422
  • Developmental toxicology in rats and rabbits
  • Multigenerational studies in rats

Standard Genetic Toxicology Studies:

  • In vitro Ames test
  • Chromosomal aberration
  • Mouse lymphoma assays
  • In vitro rodent micronucleus
  • Comet assay
  • In vitro micronucleus assay

Blue Screen HC

  • Detects direct acting mutagens
  • Data available within 72 hours of dosing

Micro Ames

  • Determines genotoxic potential
  • Highly predictive of the eventual GLP study
  • Results within 96 hours of dosing

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Physicochemical Characterization

We offer a full range of physicochemical testing to meet all regulatory requirements, either as full testing programs or stand-alone tests.

Ecotoxicology Studies

Our custom-designed ecotoxicology facility is equipped to run aquatic and terrestrial ecotoxicology investigations.

REACH Services

We offer a full range of testing services which meet REACH requirements, either as packages or stand-alone studies, conducted to the appropriate guidelines.

Skin Penetration Studies

Charles River performs
in vitro skin penetration studies with human skin to support chemical registration.