Charles River produces specific pathogen-free (SPF) chicken eggs through the use of filtered-air positive-pressure (FAPP) poultry housing, critical biosecurity measures and the careful selection of layer flocks. Validated biological assays are utilized to confirm the SPF status of every flock and compliance with USDA memorandum 800.65 and European Pharmacopoeia 5.2.2 guidelines. A quality control sheet documenting this status accompanies each product shipment. This high degree of quality control and technical expertise is continued through product processing, packing and shipping.