Overview Technical Resources OriginThe 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Transferred to Charles River under exclusive license from Pfizer, Inc., in 2011. Coat ColorBlack Ideal For:Cardiac hypertrophy, heart failure Strain Code:510 HE, 511 HO, 512 WT, This model is cryopreserved. Paper: Transgenic Model of Aldosterone-Driven Cardiac Hypertrophy and Heart Failure Genetically Engineered Model Services Dedicated Supply Backcrossing Rapid Colony Expansion
OriginThe 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Transferred to Charles River under exclusive license from Pfizer, Inc., in 2011. Coat ColorBlack Ideal For:Cardiac hypertrophy, heart failure Strain Code:510 HE, 511 HO, 512 WT, This model is cryopreserved.
Paper: Transgenic Model of Aldosterone-Driven Cardiac Hypertrophy and Heart Failure Genetically Engineered Model Services Dedicated Supply Backcrossing Rapid Colony Expansion