p110beta PI3K (exons 21/22 DEL) mice were created by The Ludwig Institute for Cancer Research and Edinburgh University.

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This model is cryopreserved.


  • PI3Kβ plays a critical role in neutrophil activation by immune complexes. Kulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K, Hirose M, Juss J, Oxley D, Chessa TA, Ramadani F, Guillou H, Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig R, Zillikens D, Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT. Sci Signal. 2011 Apr 12;4(168):ra23. doi: 10.1126/scisignal.2001617. PMID:21487106.
  • Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B.The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7.

Note: This model is also available on a B6 background.

For more information about the p110beta PI3K-DEL21/22 (129) mouse, please contact us at askcharlesriver@crl.com.