Overview Technical Resources OriginAt the Hubrecht Institute a nonsense mutation at amino acid position 59 (Glu to stop) within the catalytic center ABC transporter-like domain of the rat Abcg2 (Bcrp) gene was isolated which eliminates all wild-type protein. Transferred to Charles River under exclusive license from Transposagen in 2010. Coat ColorWhite (albino) Ideal For:ADME, drug transport, toxicology, pharmacokinetics, bioavailability, blood-brain barrier transport, stem cells, progenitor cells, proliferation, differentiation, tumor initiating cells, phototoxicity, protoporphyria, hypoxia Strain Code:497 (Heterozygous), 498 (Wild-type) Informational Resources: Bcrp TGEM® Knockout Rat Bcrp TGEM® Knockout Rat Technical Sheet
OriginAt the Hubrecht Institute a nonsense mutation at amino acid position 59 (Glu to stop) within the catalytic center ABC transporter-like domain of the rat Abcg2 (Bcrp) gene was isolated which eliminates all wild-type protein. Transferred to Charles River under exclusive license from Transposagen in 2010. Coat ColorWhite (albino) Ideal For:ADME, drug transport, toxicology, pharmacokinetics, bioavailability, blood-brain barrier transport, stem cells, progenitor cells, proliferation, differentiation, tumor initiating cells, phototoxicity, protoporphyria, hypoxia Strain Code:497 (Heterozygous), 498 (Wild-type)