Origin

Inbred from a congenic control group of Dahl/SS rats (SS/JrHsd) obtained from Dr. Theodore Kurtz (UCSF, CA) which were originally derived from the Harlan SS/Jr colony. Maintained at the Medical College of Wisconsin since 1991, this strain has undergone considerable marker-selected breeding to eliminate residual heterozygosity and genetic contamination. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested. (Cowley et al. 2000, Physiol. Genomics 2:107-115). To Charles River in 2001.

Coat Color

White (albino)

Ideal For:

hypertension, diastolic heart failure, nephropathy
NOTE: This model can be preconditioned on a diet.

Strain Code:

320

Informational Resources: Dahl/Salt Sensitive (Dahl/SS) Rat

• Dahl/SS (SS/JrHsdMcwiCrl) Rat & SS-13BN (SS-Chr 13BN/McwiCrl) Consomic Control

• Animal Models of Metabolic, Renal and Cardiovascular Disease Datasheet

Control Data

• Blood Pressure of Male Dahl/SS Rats Fed 0.3% and then 8% Salt AIN-76a Diet and Finally 0.3% Salt Purina 5L79 Diet (June 2010)

• Blood Pressure of Male Dahl/SS Rats Fed 5L79 Diet (June 2008)

• Blood Pressure of Male Dahl/SS Rats Fed 8% Salt AIN-76a Diet

• Blood Pressure Characterization of Hypertensive and Control Rats for Cardiovascular Studies (2008)

• Clinical Pathology Data for North American Dahl/Salt Sensitive Rat Colonies for January 2010 - December 2011

Diet Information for Enhancing or Expressing the Desired Disease Condition:

Environmental Hypertension, Nephrology, and Cardiomyopathy

• Purina: AIN-76A

• Research Diets: AIN -76A