Co-developed by Nanjing Biomedical Research Institute of Nanjing University and Nanjing Galaxy Biopharma in 2014 and transferred to Charles River in 2016. This model was created by sequential CRISPR/Cas9 editing of the Prkdc and Il2rg loci in the NOD/Nju mouse, generating a mouse coisogenic to the NOD/Nju. The NOD/Nju carries a mutation in the Sirpa (SIRP α) gene that allows for engrafting of foreign hematopoietic stem cells. The Prkdc knockout generates a SCID-like phenotype lacking proper T-cell and B-cell formation. The knockout of the Il2rg gene further exacerbates the SCID-like phenotype while additionally resulting in a decrease of NK cell production.
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Oncology, immunology, infectious disease, graft vs. host disease, diabetes, regenerative medicine and human organ transplantation
Informational Resources: NCG Mouse
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NCG Mouse Health Report
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Whether it’s PDX or xenograft cell lines, we have validated a number of different types of models for running immuno-oncology evaluation studies.