Most commonly called the NIH-III, it was developed at NIH. In addition to the nude gene, which results in the absence of thymus and T-cell function, this mouse has two other mutations important in regulating the function of the immune system. These are designated as x-linked immune defect (xid) and beige (bg). The xid mutation affects the maturation of T-independent B lymphocytes. It has been demonstrated that bg homozygotes have defective natural killer (NK) cells that are cytotoxic in vitro to tumor cells. However, the extent of the T-independent B lymphocyte and NK cell deficiencies in the NIH-III have not been established.
Hairless, light to dark gray pigmented skin
Tumor biology and xenograft research
201 (Homozygous), 202 (Heterozygous)
Informational Resources: NIH III Mouse
Growth Chart Not Available
NIH-III Mouse (Heterozygous) Health Reports
NIH-III Mouse (Homozygous) Health Reports
*This pricing is subject to our General Terms & Conditions of Sale.
The Charles River Animal Model Evaluation Program allows you to assess the quality and compatibility of our animal models before making a commitment.
Our Pre-ID™ services enable you to receive animal models that have been identified with the codes you provide us.
Precautionary screening should be performed to confirm that biologics are free of infectious agents and are originating from the appropriate host species.