Overview Technical Resources OriginNSE-p25 mice were created by pronuclear injection of an NSE-p25 transgene, produced internally at Pfizer, with transplantation of embryos to pseudopregnant CD-1 females. At weaning genomic DNA was isolated from tail tissue and founder transgenics were identified by PCR that specifically amplified DNA sequences from the human p25 cDNA. Founder mice were bred to FVB/N mates and transgenic offspring were used to maintain the transgenic line. Transferred to Charles River in 2011. Coat ColorWhite (albino) Ideal For:Alzheimer's disease Strain Code:528 HE, 529 HO, 530 WT, This model is cryopreserved. Paper: Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5 Genetically Engineered Model Services Dedicated Supply Backcrossing Rapid Colony Expansion
OriginNSE-p25 mice were created by pronuclear injection of an NSE-p25 transgene, produced internally at Pfizer, with transplantation of embryos to pseudopregnant CD-1 females. At weaning genomic DNA was isolated from tail tissue and founder transgenics were identified by PCR that specifically amplified DNA sequences from the human p25 cDNA. Founder mice were bred to FVB/N mates and transgenic offspring were used to maintain the transgenic line. Transferred to Charles River in 2011. Coat ColorWhite (albino) Ideal For:Alzheimer's disease Strain Code:528 HE, 529 HO, 530 WT, This model is cryopreserved.
Paper: Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5 Genetically Engineered Model Services Dedicated Supply Backcrossing Rapid Colony Expansion