Origin

From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002.
These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.

Coat Color

Black

Ideal For:

Immunology, Inflammation and Autoimmunity Research

Strain Code:

N/A

References for OT I Mouse

  • Didierlaurent AM, Collignon C, Bourguignon P, Wouters S, Fierens K, Fochesato M, Dendouga N, Langlet C, Malissen B, Lambrecht BN, Garçon N, Van Mechelen M, Morel S. Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells. Journal of Immunology: epub ahead of print 2014 July 14

For more information about OT I mice, please contact us at askcharlesriver@crl.com.

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