Overview Technical Resources OriginFrom the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient. Coat ColorBlack Ideal For:Immunology, Inflammation and Autoimmunity Research Strain Code:N/A For more information about OT I mice, please contact us at askcharlesriver@crl.com.
OriginFrom the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient. Coat ColorBlack Ideal For:Immunology, Inflammation and Autoimmunity Research Strain Code:N/A