Overview Technical Resources OriginIn 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), that were developed in conjunction with Merck by Charles River Genetically Engineered Models and Services in Wilmington, MA. Coat ColorWhite (albino) Ideal For:PGP-deficient blood brain barrier model, CNS, transport/excretion involving mds (multiple drug sensitive) for neurobiology and chemotherapy, toxicology, teratology, altered intestinal intraepithelial lymphocyte development Strain Code:291, 292 (Wild-type) Informational Resources: PGP Mouse Health Monitoring of Charles River Barrier Production Colonies in Europe and North America Technical Reference The CF-1 Mutant Mouse: A P-glycoprotein Deficient Model
OriginIn 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), that were developed in conjunction with Merck by Charles River Genetically Engineered Models and Services in Wilmington, MA. Coat ColorWhite (albino) Ideal For:PGP-deficient blood brain barrier model, CNS, transport/excretion involving mds (multiple drug sensitive) for neurobiology and chemotherapy, toxicology, teratology, altered intestinal intraepithelial lymphocyte development Strain Code:291, 292 (Wild-type)
Informational Resources: PGP Mouse Health Monitoring of Charles River Barrier Production Colonies in Europe and North America Technical Reference The CF-1 Mutant Mouse: A P-glycoprotein Deficient Model
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