Overview Technical Resources OriginThe RIP-HAT rat was created utilizing the RIPHAT transgene consisting of a PCR-generated cDNA encompassing the h-IAPP coding sequence under the regulation of the rat insulin II promoter/5’untranslated region and followed by intron I from the human albumin gene and the polyadenylation site/RNA termination region from the human glyceraldehydes-3-phosphate gene. The construct was microinjected into fertilized Sprague Dawley eggs to generate the founder rats. Transferred to Charles River for distribution in 2011. Coat ColorWhite (albino) Ideal For:Diabetes Strain Code:504 HO, 505 HE, 506 WT Paper: Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat) Genetically Engineered Model Services Dedicated Supply Backcrossing
OriginThe RIP-HAT rat was created utilizing the RIPHAT transgene consisting of a PCR-generated cDNA encompassing the h-IAPP coding sequence under the regulation of the rat insulin II promoter/5’untranslated region and followed by intron I from the human albumin gene and the polyadenylation site/RNA termination region from the human glyceraldehydes-3-phosphate gene. The construct was microinjected into fertilized Sprague Dawley eggs to generate the founder rats. Transferred to Charles River for distribution in 2011. Coat ColorWhite (albino) Ideal For:Diabetes Strain Code:504 HO, 505 HE, 506 WT
Paper: Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat) Genetically Engineered Model Services Dedicated Supply Backcrossing