SCID mice possess a genetic autosomal recessive mutation Prkdcscid. Discovered in 1980 by Bosma in C.B-17/Icr mice at Fox Chase Cancer Center. SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal natural killer (NK) cells, macrophages and granulocytes. NCI received this mouse in 1991. To Charles River in 2014.
tumor biology and xenograft research
Informational Resources: SCID NCr Mouse
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NCI SCID/N Mouse Health Reports
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