Origin

Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure. Brother x sister mating with continued selection for spontaneous hypertension was then started. To NIH in 1966 from Okamoto at F13. To Charles River from NIH in 1973 at F32.

Coat Color

White (albino)

MHC Haplotype

RT1^k

Ideal For:

genetic hypertension, hypertensive drug research, ADHD model, safety and efficacy testing

Strain Code:

007

Informational Resources: Spontaneously Hypertensive (SHR) Rat

• Animal Models of Metabolic, Renal and Cardiovascular Disease Datasheet

Baseline Colony Data

• Biochemistry and Hematology for SHR Rat Colonies in North American for January 2010 – December 2011

• Pulse Pressure for SHR/NCrl Rat Colony Fed 5L79 Diet (January – June 2007)

• Blood Pressure for Female SHR/NCrl Rat Colony (Female Data Set 1: February - June 2007)

• Blood Pressure for Male SHR/NCrl Rat Colony (Male Data Set 3: Male Data Set 1 & 2 combined)

• Blood Pressure for Male SHR/NCrl Rat Colony (Male Data Set 2: January - June 2007)

• Blood Pressure for Male SHR/NCrl Rat Colony (Male Data Set 1: March - June 2006)

• Blood Pressure Characterization of Hypertensive and Control Rats for Cardiovascular Studies