Origin

This mutation occurred in the laboratory of Dr. Simon Koletsky in 1969 at Case Western Reserve University School of Medicine. It was developed from a cross between a hypertensive female rat and a normotensive male Sprague Dawley rat. The colony was maintained as brother x sister matings in a closed colony at Case Western Reserve University School of Medicine since 1971. To Genetic Models, Inc. in 2000. To Charles River in 2001.

Coat Color

White (albino)

Ideal For:

hypertension, hyperinsulinemia, obesity, nephropathy, metabolic syndrome, hyperlipidemia

Strain Code:

375 (Obese), 376 (Lean +/?)

Informational Resources: Spontaneously Hypertensive Obese (SHROB) Rat

• Animal Models of Metabolic, Renal and Cardiovascular Disease Datasheet

Technical Data

• High Dietary Sodium Provokes Development of Hypertension in Lean SHROB Rat

Diet Information for Enhancing or Expressing the Desired Disease Condition:

• Hypertension, Obesity, and Metabolic Disease: Purina- 5L79