Overview Technical Resources OriginThis model was isolated from a C57BL/6NCrl colony in a Charles River Laboratories barrier facility in the United States in 2005. The mutation was mapped to a region within less than 2 cM of the leptin receptor on Chr 4. Lack of leptin receptor protein. Het x Het mating. Coat ColorBlack Ideal For:obesity, hyperinsulinemia, insulin resistance, dyslipidemia, metabolic syndrome, leptin receptor deficiency, fatty liver disease Strain Code:457 (Obese), 464 (Lean +/?) Informational Resources: The Pound ® Mouse THE POUND MOUSE™: A Model for Metabolic Syndrome/Pre-Diabetes Animal Models of Metabolic, Renal and Cardiovascular Disease Datasheet Baseline Data Comparison of Insulin Levels for the C57BL/6NCrl-Lepr db-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Glucose Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Cholesterol Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Leptin Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Triglyceride Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Body Weights for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006
OriginThis model was isolated from a C57BL/6NCrl colony in a Charles River Laboratories barrier facility in the United States in 2005. The mutation was mapped to a region within less than 2 cM of the leptin receptor on Chr 4. Lack of leptin receptor protein. Het x Het mating. Coat ColorBlack Ideal For:obesity, hyperinsulinemia, insulin resistance, dyslipidemia, metabolic syndrome, leptin receptor deficiency, fatty liver disease Strain Code:457 (Obese), 464 (Lean +/?)
Informational Resources: The Pound ® Mouse THE POUND MOUSE™: A Model for Metabolic Syndrome/Pre-Diabetes Animal Models of Metabolic, Renal and Cardiovascular Disease Datasheet Baseline Data Comparison of Insulin Levels for the C57BL/6NCrl-Lepr db-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Glucose Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Cholesterol Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Leptin Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Triglyceride Levels for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006 Comparison of Body Weights for the C57BL/6NCrl-Leprdb-lb/Crl (THE POUND MOUSE™) and Other Mouse Models Fed Purina 5008 Diet October 2006