Origin

A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001. *Note: We recommend male obese ZDF rats be fed Purina #5008 diet to induce programmed and consistent development of Type 2 diabetes. Female obese ZDF rats express a reproducible Type 2 diabetes phenotype when fed D12468 from Research Diets, Inc.

Coat Color

Black hooded with black stripe down the length of the back

Ideal For:

Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia

Strain Code:

370 (Obese), 380 (Lean fa/+), 371 (Lean +/?)

Informational Resources: ZDF (Zucker Diabetic Fatty) Rat

• Diet Evaluation Study for the Induction of Type 2 Diabetes in Obese Female ZDF Rats

• Animal Models of Metabolic, Renal and Cardiovascular Disease Datasheet

Baseline Colony Data

• Biochemistry and Hematology for ZDF Rat Colonies in North American for January 2008 – December 2010

• Blood Glucose Values for Obese Male ZDF Rats Fed Purina 5008 (Kingston, NY; March 2010 – October 2010)

• Fed Glucose and Insulin Values for Obese Male ZDF Rats Fed Purina 5008 (January 2010 – July 2010)

• Blood Glucose Values for Obese Male ZDF Rats Fed Purina 5008 (Kingston, NY - July 2009)

• Cholesterol Levels for Obese Male ZDF Fed IR Purina 5008 (Portage, MI and Kingston, NY - September 2005)

• Insulin Values for Obese Male ZDF Rats Fed IR Purina 5008 (Portage, MI and Kingston, NY - September 2005)

• Triglyceride Levels for Obese Male ZDF Rats Fed IR Purina 5008 (Portage, MI and Kingston, NY - September 2005)

• Oral Glucose Tolerance Test on Obese Male ZDF Rats Fed IR Purina 5008 (Portage, MI and Kingston, NY - September 2005)

• Weight Chart for Obese Male ZDF Rats Fed IR Purina 5008 (Portage, MI and Kingston, NY - September 2005)

Diet Information for Enhancing or Expressing the Desired Disease Condition:

• Type 2 Diabetes (Female ZDF): Research Diets- D12468

• Type 2 Diabetes (Male ZDF): Purina- 5008