Mouse Embryo Assay

Our high-throughput embryology laboratory offers the mouse embryo assay to screen media and materials for toxicity prior to lot release. The mouse embryo assay (MEA) is currently the most widely used bioassay to test for toxicity and functionality of media and materials. Our laboratory can perform these assays seven days a week under GLP conditions, enabling a quick turnaround time. As with all of our services, our MEA testing is supported by a vast network of PhD-level scientists to ensure accurate, high-quality results.

The Mouse Embryo Assay (MEA) is used for toxicity and functionality testing of media, labware, disposables or any device which may come into contact with gametes or embryos.

  • Fresh or frozen one- or two-cell embryos from a cross between B6D2F1/Crl x B6C3F1/Crl
  • A minimum of 25 embryos per test article and 15 control embryos
  • Assessment of embryos at 72, 96 or 120 hours; minimum of 80% blastocyst development required for passing test
  • Repeat testing performed after failure at no charge
  • Sample receipt 7 days a week; testing typically completed within 7 days
  • General protocols consist of exposing test article to embryos through wash or long-term culture. Disposables, labware or devices are typically flushed with media prior to setting up culture drops for long-term culture.

The information above is only meant as a guideline. Individual testing protocols can be established to suit your individual requirements.

Mouse Embryos

Embryos are available to perform this assay yourself or practice other techniques.