The biosafety package for any biopharmaceutical product must include a comprehensive plan for the detection of adventitious and endogenous viral agents. Charles River offers a portfolio of in vivo, in vitro and biochemical assays to detect these viruses. Assays can be chosen and customized to address your specific concerns and needs, ensuring that an appropriate testing plan is designed for your product.
In Vivo Assays
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Mouse, hamster and rat antibody production (MAP, HAP, RAP) test
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Adventitious viruses assays, including specific assays for the testing of vaccines
Cell-Based In Vitro Assays
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14- and 28-day adventitious virus assays
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Porcine and bovine adventitious virus assays
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Customized assays addressing specific contamination risks
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Retrovirus detection assays
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XC plaque assay
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S+L- focus assay
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Transmission electron microscopy (TEM)
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Co-cultivation assays (murine, ecotropic, amphotropic and rodent)
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PCR-based reverse transcriptase (PBRT) assay
Species-Specific Viral PCR Assays
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Standard and qPCR techniques available for RNA and DNA viruses
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Method development available for customized assays
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Rapid, sensitive and specific broad-range PCR assays for adenoviruses, herpesviruses, papillomaviruses and polyomaviruses