Glycosylation / Glycan Characterization

Charles River offers an expert panel of services for the characterization of glycosylation. We specialize in comparability programs that may be used for manufacturing/process changes and for comparisons of originator vs. biosimilar products.

  • Glycosylation Site Occupancy and Mapping via Peptide Mapping LC-MS/MS
  • N-Linked Oligosaccharide Profile via LC-MS/MS
  • O-Linked Oligosaccharide Profile via LC-MS/MS
  • Quantitative Monosaccharide Analysis
  • Quantitative Sialic Acid Determination
  • Glycan Structural Characterization / Confirmation via MSn
  • Glycan Profile / Isoform via cIEF
  • Exoglycosidase Glycan Sequence / Mapping

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Glycoprotein Characterization

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Bioanalysis Support

Our scientists work closely with our immunogenicity, pharmacokinetic and statistical specialists to deliver the pertinent solutions and interpretations applicable to your molecule and study.

Potency Testing

Charles River is able to provide expert opinions and services for the development and validation of in vivo and in vitro bioassays.