Mass Spectrometry With extensive experience managing complex projects, our state-of-the-art mass spectrometry laboratory consistently delivers excellent structural characterization services to our clients. Our LC-UV/MS and LC-MS/MS offerings include: Intact and Subunit Molecular Weight Determination Antibody Drug Conjugate (ADC) Characterization and Stoichiometry Determination Glycosylation Site Mapping/Occupancy Disulfide Bridge Mapping; Disulfide Bonding Conformations/Isoforms via Peptide Mapping LC-MS Post-Translational Modification (PTM) Mapping: Sulfation, Phosphorylation, Myristoylation, etc. Degradation / Stability analysis including oxidation and deamidation Glycan Structural Characterization Chromatographic “Fingerprint Analysis” Degradation / Impurity Characterization de novo Amino Acid Sequencing and Sequence Verification Pharmacokinetic (PK) Profiling and Pharmacodynamic (PD) GLP Method Development and Validation Peptide Mapping Method Development, ICH Validation, and GMP Lot Release Support PEGylation Site Mapping GAGS, Heparan and Heparan Sulfate Analysis Biosimilar Comparability/Characterization Programs Reference Standard Characterization Isoform Characterization You may also be interested in... The Analytical Challenges of the Biosimilar Boom With the acceleration in the development of biosimilars, we are starting to see an imbalance in the industry. This will manifest in several ways, including financial, market competition, innovation and geographic redistribution. As a result, the biologics industry is due for substantial changes. Article: "Mass Spectrometry Measures Up to Analytical Challenges" Mario DiPaolo, senior scientific director for Charles River Laboratories, speaks with a writer from BioPharm International in this scientific article. Quantitation of Heparan Sulfate using Multiple Mass Spec Methods This work describes the development of a robust and sensitive method to quantify HS in serum and other biological matrices using a triple quadrupole mass spectrometer. Outsourcing Biosimilars Development: A Discussion Niall Dinwoodie, Global Coordinator of Analytical Testing at Charles River, speaks to BioProcess International about his perspective on the current issues in biosimilar outsourcing.