Mass Spectrometry With extensive experience managing complex projects, our state-of-the-art mass spectrometry laboratory consistently delivers excellent structural characterization services to our clients. Our LC-UV/MS and LC-MS/MS offerings include: Intact and Subunit Molecular Weight Determination Antibody Drug Conjugate (ADC) Characterization and Stoichiometry Determination Glycosylation Site Mapping/Occupancy Disulfide Bridge Mapping; Disulfide Bonding Conformations/Isoforms via Peptide Mapping LC-MS Post-Translational Modification (PTM) Mapping: Sulfation, Phosphorylation, Myristoylation, etc. Degradation / Stability analysis including oxidation and deamidation Glycan Structural Characterization Chromatographic “Fingerprint Analysis” Degradation / Impurity Characterization de novo Amino Acid Sequencing and Sequence Verification Pharmacokinetic (PK) Profiling and Pharmacodynamic (PD) GLP Method Development and Validation Peptide Mapping Method Development, ICH Validation, and GMP Lot Release Support PEGylation Site Mapping GAGS, Heparan and Heparan Sulfate Analysis Biosimilar Comparability/Characterization Programs Reference Standard Characterization Isoform Characterization You may also be interested in... Biosimilar Development Webinar Replay Watch an overview on the stages of biosimilar development and how companies can use CROs to expedite this process. Article: "Mass Spectrometry Measures Up to Analytical Challenges" Mario DiPaolo, senior scientific director for Charles River Laboratories, speaks with a writer from BioPharm International in this scientific article. Quantitation of Heparan Sulfate using Multiple Mass Spec Methods This work describes the development of a robust and sensitive method to quantify HS in serum and other biological matrices using a triple quadrupole mass spectrometer. The Role of Mass Spectrometry in Demonstrating Biosimilarity View our webinar replay where we provide an overview of how various mass spectrometry techniques can be used for the characterization of biosimilars.