Mass Spectrometry With extensive experience managing complex projects, our state-of-the-art mass spectrometry laboratory consistently delivers excellent structural characterization services to our clients. Our LC-UV/MS and LC-MS/MS offerings include: Intact and Subunit Molecular Weight Determination Antibody Drug Conjugate (ADC) Characterization and Stoichiometry Determination Glycosylation Site Mapping/Occupancy Disulfide Bridge Mapping; Disulfide Bonding Conformations/Isoforms via Peptide Mapping LC-MS Post-Translational Modification (PTM) Mapping: Sulfation, Phosphorylation, Myristoylation, etc. Degradation / Stability analysis including oxidation and deamidation Glycan Structural Characterization Chromatographic “Fingerprint Analysis” Degradation / Impurity Characterization de novo Amino Acid Sequencing and Sequence Verification Pharmacokinetic (PK) Profiling and Pharmacodynamic (PD) GLP Method Development and Validation Peptide Mapping Method Development, ICH Validation, and GMP Lot Release Support PEGylation Site Mapping GAGS, Heparan and Heparan Sulfate Analysis Biosimilar Comparability/Characterization Programs Reference Standard Characterization Isoform Characterization You may also be interested in... Biosimilar Webinar Series Replay Experts elaborate on aspects of biosimilar development such as potency determination, structural characterization and bioanalytical assay requirements. Article: "Mass Spectrometry Measures Up to Analytical Challenges" Mario DiPaolo, senior scientific director for Charles River Laboratories, speaks with a writer from BioPharm International in this scientific article. Quantitation of Heparan Sulfate using Multiple Mass Spec Methods This work describes the development of a robust and sensitive method to quantify HS in serum and other biological matrices using a triple quadrupole mass spectrometer. Upcoming Seminar Join us for this luncheon seminar as two of our scientists discuss the analytical methods used to detect process residuals and determine biosimilarity. Also discussed will be a mass spectrometry approach to determine multiple product quality attributes.