Orthogonal Screening Platforms

Charles River offers a wide range of orthogonal platforms for primary screening, fragment screening, hit confirmation and characterization, hit-to-lead and lead optimization. Targets are addressed individually, and the most efficient and pharmacologically relevant solution is provided.

Surface Plasmon Resonance (SPR)
  • Biacore 4000 for high-throughput hit identification
  • Biacore T200 with added sensitivity for kinetic profiling, mechanistic analysis and backup screening
High-Concentration Biochemical Assays
  • Multi-modal fluorescence and luminescence readouts
  • Electrophoretic mobility (Caliper)
  • Binding assays and other high-concentration biochemical assays
X-ray Crystallographic Screening
  • In-house X-ray facility with synchrotron access 
  • Crystal bank of structures
Native Mass Spectrometry
  • Label-free technology for detecting protein-ligand complexes in their native state
  • Highly sensitive and information rich (binding mode, affinity and stoichiometry)

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Screening Libraries

We offer one of the most powerful screening platforms in the industry with over 850,000 unique chemical compounds.

Hit-to-Lead

We conduct hit-to-lead projects in an efficient cycle of rational design, synthesis and biological evaluation.

lab tech conducting biological sample processing in a hood

Integrated Drug Discovery

We operate as a proactive thinking partner bringing target to clinical candidate capabilities, ideas and solutions to your program.