Biotransformation

Biotransformation describes the conversion of a compound to a metabolite through the action of enzymes. Charles River offers a comprehensive service for the isolation, analysis and identification of metabolites in biological matrices in support of drug safety studies. This service can be provided as part of a full ADME package or as a stand-alone study.

Additionally, a synthetic chemistry service is available to undertake synthesis of metabolites, reference standards and internal standards to assist with method development and metabolite identification.

Technical Capabilities

  • Radiometric profiling
  • HPLC/UPLC
  • LC-MS and LC-MS/MS
  • GC-MS and ion trap MS
  • CE for oligonucleotides
  • TOF, MALDI-TOF and ion mobility
  • Organic chemistry metabolite synthesis

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Surgical Models

A range of surgical models for use in any drug metabolism, pharmacology or safety study type.

Radioanalysis

Samples from any metabolism program can be analyzed in our dedicated radioanalysis laboratories.

The Source℠

Our secure portal for direct access to technical, scientific and educational resources including webinars, posters and videos.

<i>In Vitro</i> Services

In Vitro Services

Our in vitro services provide support for metabolic investigations with both qualitative and quantitative data.