Non-GLP Toxicology

Charles River provides services in non-GLP bioavailability, pharmacokinetics and toxicity analysis in addition to in vitro assays designed to assess the cytotoxic, genotoxic and cardiotoxic potential of candidate molecules.

Acute Toxicity Testing

  • Timed dosing and sampling
  • Tissue and/or organ preservation
  • Plasma and/or serum sampling
  • Histology and pathology
  • CBC with differentials

In vitro Cytotoxicity Testing

  • Cell viability: ATP and MTS endpoint
  • Membrane integrity: LDH endpoint
  • Apoptosis: caspase-3/7 endpoint

Genotoxicity Testing

  • BlueScreen assay
  • MicroAmes assay
  • Micro in vitro micronucleus test

Skin Penetration Testing

Cardiotoxicity Testing

  • hERG channel blockade

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Streamlined Non-GLP Acute Toxicology Studies

Our new streamlined protocols, redesigned in-life procedures and targeted reports allow us to offer an operationally efficient service with a more flexible pricing structure. Redesigning our approaches translates directly into savings, without compromising objectives and quality.