Crystal Bank

Charles River has experience with many targets of pharmaceutical interest covering a range of gene families, including kinases (Ser/Thr and Tyr), phosphodiesterases, nuclear hormone receptors, and proteases such as deubiquitinases and other epigenetic targets.

Crystal Bank is a library of >75 proteins with known routes to structure, which can be used to speed up the analysis of your protein/ligand complexes by X-ray crystallography. Some of the proteins currently available are listed below:

Crystal Bank Proteins
Kinases Epigenetic Targets
Aurora A BRD2 BD1
Aurora C/INCENP BRD2 BD2
ALK BRD4 BD1
ASK1 BRD4 BD2
ITK CREBBP
JAK2 USP2
SYK Phosphodiesterases
GSK3B PDE1B
PI3K gamma PDE2A
JNK3 PDE4B catalytic domain
CDK2/cyclin A2 PDE4B catalytic domain + UCR
CDK2 PDE4D catalytic domain
MKK7 PDE5
PDHK-2 PDE7B
TMK (human) PDE9A
TMK (C. albicans) PDE10A
P38 alpha Others
TRKA Bcl2
ALK5 Fatty acid synthase/thioesterase domain
BMX CD81
PLK4 HCV polymerase
ZAP70 HIV capsid
Proteases HIV integrase
Aminopeptidase N HIV matrix
Carboxypeptidase B HIV reverse transcriptase
Caspase-1 KEAP1
Caspase-6 LDHA
HCV protease NMT (C. albicans)
uPA NMT (human)
BACE-1 PIN-1
MMP3 hPGDS
MMP8 Arginase II
Thrombin ACCase (C. albicans)
HNE Cyclophilin A
Adipsin Cyclophilin B
Nuclear Hormone Receptors Cyclophilin D
Androgen receptor FKBP12
Estrogen receptor alpha P450 2C9
Estrogen receptor beta P450 3A4
PPAR delta  

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