Cardiac action potential duration (APD) assays are recommended for candidate selection and Investigational New Drug (IND) submissions.
APD SC-derived Human Cardiomyocytes
Manual patch clamp recordings of action potentials in isolated induced pluripotent stem cell-derived human cardiomyocytes (SC-hCMs) evaluate paced intracellular electrical response for detection of drug-induced action potential prolongation and arrhythmia.
Detection of action potential prolongation (QT risk) and EADs (trigger for torsades de pointes)
Stable recordings at physiological temperature with minimal diffusion delays
Human test system
APD Purkinje Fiber
Intracellular recordings of action potentials in animal Purkinje fibers evaluate paced electrical response for detection of drug-induced action potential prolongation and arrhythmia.
The APD assay, together with the hERG assay, is an effective indicator of multiple ion channel effects (MICE).
Assays available as GLP or non-GLP