SoftFocus® Subscription Libraries

Screening small, focused libraries of novel compounds designed to address your biological target can:

  • provide valuable SAR and higher hit rates compared to diverse screening
  • give an improved chance of securing intellectual property (IP)
  • provide quality starting points for emerging or complex targets, if designed to contain the necessary features and shape
  • demonstrate utility in phenotypic screens

SoftFocus® compound libraries have delivered outstanding success to partners that have screened them, as evidenced by numerous patents and published papers, and have led to several clinical candidates.

New SoftFocus® libraries are designed and launched each year and can be accessed through a shared exclusivity model, whereby access to each library is restricted to a maximum of 15 partners. For more information, download the SoftFocus® Compound Libraries Flyer.

Current design targets
Epigenetic Libraries:
  • histone methyltransferase (HMT)
  • histone lysine demethylases (KDM)
  • bromodomains
Protein-Protein Interactions (PPI) Libraries:
  • secondary structure mimetics
  • ‘hot-spot’ targets
  • macrocyclic libraries
Kinase Libraries:
  • hinge binding
  • ‘DFG-out’
  • invariant lysine binding
GPCR Libraries:
  • Family A (including chemokine and lipid receptors)
  • Family C, such as mGluR
Ion Channel Libraries:
  • voltage-gated libraries (VGIC)
  • ligand-gated (LGIC)
  • transient receptor potential channels (TRP channels)

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