Biotransformation describes the conversion of a compound to a metabolite through the action of enzymes. Charles River offers a comprehensive service for the isolation, analysis and identification of metabolites in biological matrices in support of drug safety studies. This service can be provided as part of a full ADME package or as a stand-alone study.

Additionally, a synthetic chemistry service is available to undertake synthesis of metabolites, reference standards and internal standards to assist with method development and metabolite identification.

Technical Capabilities

  • Radiometric profiling
  • LC-MS and LC-MS/MS
  • GC-MS and ion trap MS
  • CE for oligonucleotides
  • TOF, MALDI-TOF and ion mobility
  • Organic chemistry metabolite synthesis

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Surgical Models

A range of surgical models for use in any drug metabolism, pharmacology or safety study type.


Samples from any metabolism program can be analyzed in our dedicated radioanalysis laboratories.

The Source℠

Our secure portal for direct access to technical, scientific and educational resources including webinars, posters and videos.

<i>In Vitro</i> Services

In Vitro Services

Our in vitro services provide support for metabolic investigations with both qualitative and quantitative data.