Charles River designs and conducts GLP-compliant quantitative whole-body autoradiography (QWBA) programs integrated with our preclinical drug metabolism services. In addition to providing a quantitative measure of distribution, the high-resolution digital image obtained from a phosphorimager can be enlarged to provide greater depth and detail of distribution in the tissues or organ of interest.

MALDI-MSI (Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging) provides a label-free imaging alternative for the detection and localization of drugs and drug metabolites. Ideally suited to assessing the intra-organ distribution of drugs (and metabolites), MALDI-MSI can be successfully adapted to provide whole-body images in small rodent species. Furthermore, using proprietary software, quantitative data can be produced.

  • Tissue distribution
  • Target organ/tissue validation
  • Correlation with histopathology
  • Placental transfer
  • Penetration of blood-brain barrier
  • Tumor penetration
  • Support of micronucleus test
  • Human dosimetry calculations
  • Dermal/ungual penetration
  • Carbon-14
  • Gadolinium-153
  • Iodine-125
  • Phosphorus-32
  • Strontium-89
  • Sulfur-35
  • Iron-59
  • Tritium
  • Other beta or gamma emitters

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Charles River can develop, validate and apply quantitative bioanalytical methods for small molecules and larger proteins.

Microautoradiography Researcher

In what appears to be the first application for such a type of investigation, Charles River used QWBA techniques to investigate the tissue distribution of radioactivity in the minipig. (Available in the Source℠)

Scientific Poster

Access our QWBA poster titled “The Simultaneous Use of Multiple Imaging Techniques to Investigate the Nature and Localisation of Radioactivity within Micro-structures Surrounding the Rat Brain,” presented at EUROTOX 2014.

lab technician on computer in animal barrier room

Toxicology Studies

Leading the industry in the fields of reproductive toxicology, inhalation, infusion, bone research and other specialty toxicological assessments.