CVN Mouse | Tg2576 Mouse | Scopalamine-Induced Amnesia Model
Tg2576 mice overexpress a mutant form of amyloid precursor protein (APP), APPK670/671L, linked to early-onset familial Alzheimer’s disease (AD), developing amyloid plaques and progressive cognitive deficits. The Charles River AD platform with the Tg2576 mouse includes cognitive testing, measurement of the levels of soluble and insoluble beta amyloid, and immunohistochemical measurements. All studies can be customized according to client needs.
The Tg2576 mouse shows impaired cognitive functions in the contextual fear conditioning test, coinciding with the increased cortical and hippocampal soluble beta amyloid levels, starting from 5 months of age. The increased insoluble beta amyloid levels and the amyloid plaques are evident at 13 months of age.
Behavioral and Cognitive Tests
Motor Functions: Open Field Test
Total distance traveled
Distance traveled in the center area
Total rearing frequency
Rearing rate in the center area
Multiple other variables
Cognitive Deficits: Contextual Fear Conditioning Test (CFC)
Memory for context
Memory for cue
Testing / Validation Data
Click below to see a sample data set.