Charles River conducts contract studies in an established spinal nerve ligation (SNL) model in rats to test the efficacy of novel compounds. Considered one of the most suitable models for analgesia screening against neuropathic pain, our SNL model is induced by unilateral ligation of the L5 and L6 branches of the spinal nerves.
Stable mechanical tactile allodynia, as assessed by manual von Frey filaments, is observed from week 1 up to week 7 post-surgery. In addition to tactile allodynia, the model can be optimized for other endpoints such as heat hyperalgesia and weight bearing based on client’s request.
Testing / Validation Data
Click below to see a sample data set.