SoftFocus® Subscription Libraries

Screening small, focused libraries of novel compounds designed to address your biological target can:

  • provide valuable SAR and higher hit rates compared to diverse screening
  • give an improved chance of securing intellectual property (IP)
  • provide quality starting points for emerging or complex targets, if designed to contain the necessary features and shape
  • demonstrate utility in phenotypic screens

SoftFocus® compound libraries have delivered outstanding success to partners that have screened them, as evidenced by numerous patents and published papers, and have led to several clinical candidates.

New SoftFocus® libraries are designed and launched each year and can be accessed through a shared exclusivity model, whereby access to each library is restricted to a maximum of 15 partners. For more information, download the SoftFocus® Compound Libraries 2015 Flyer.

Current design targets
Epigenetic Libraries:
 
  • histone methyltransferase (HMT)
  • histone lysine demethylases (KDM)
  • bromodomains
Protein-Protein Interactions (PPI) Libraries:
 
  • secondary structure mimetics
  • ‘hot-spot’ targets
  • macrocyclic libraries
Kinase Libraries:
  • hinge binding
  • ‘DFG-out’
  • invariant lysine binding
GPCR Libraries:
  • Family A (including chemokine and lipid receptors)
  • Family C, such as mGluR
Ion Channel Libraries:
  • voltage-gated libraries (VGIC)
  • ligand-gated (LGIC)
  • transient receptor potential channels (TRP channels)

You may also be interested in...

Library Design

Take advantage of the insights our scientists have gained through 15 years of library design by using our custom library design service.

Medicinal Chemistry

Our medicinal chemistry team is among the best in the world with many of our scientists bringing a wealth of experience from previous employment in the pharma and biotech industries.

Integrated Drug Discovery

Integrated Drug Discovery

We operate as a proactive thinking partner bringing target to clinical candidate capabilities, ideas and solutions to your program.