Primary cultures offer fast access to study molecules of interest directly in relevant cell types. Primary cultures are real cells present in tissue instead of immortalized cell lines and are good tools for lead compound identification (efficacy and toxicity screening).
Charles River conducts contract studies in an established in vitro model of neurodegeneration to assess the efficacy of novel compounds. The ability to promote growth of neurites is an important feature of compounds for CNS degenerative diseases (e.g., stroke, Alzheimer’s disease). Primary cortical and hippocampal cultures outgrow actively, and the effect of compounds on a number of processes and branches, as well as on the length of neurites, are studied using these cultures. Data is available within few weeks from study initiation.
Testing / Validation Data
Click below to see a sample data set.