Primary cultures offer access to study molecules of interest directly in relevant cell types. Primary cultures are real cells present in tissue instead of immortalized cell lines and are good tools for lead candidate identification (efficacy and toxicity screening).
Charles River conducts contract studies in an established in vitro model of Parkinson's disease to assess the efficacy of novel compounds. In Parkinson’s disease pathology, midbrain neurons and dopaminergic signaling are severely affected. The effect of 6-hydroxydopamine (6-OHDA) on dopaminergic neurons identified by tyrosine hydroxylase immunocytochemistry can be studied. LDH is measured as a marker for general cell death. Data is available within few weeks from study initiation.
Testing / Validation Data
Click below to see a sample data set.