The most important components of tissue damage in stroke are deprivation of oxygen and glucose, excitotoxicity (excess release of glutamate from affected cells) and production of harmful free radicals. Our in vitro model battery for stroke provides access to all these mechanisms involved in stroke. The possible exposures include:
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Oxygen-glucose deprivation
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Glutamate-induced excitotoxic insult
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Hydrogen peroxide-induced free radical insult
Primary cultures offer fast access to study molecules of interest directly in relevant cell types. Primary cultures are real cells present in tissue instead of immortalized cell lines and are good tools for lead molecule identification (efficacy and toxicity screening). Data is available within few weeks from study initiation.
Testing / Validation Data
Click below to see a sample data set.